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1. Grief, Brokenheartedness, Heartache, Heartbreak : غم - رنج : (Noun) Intense sorrow caused by loss of a loved one (especially by death).

She is suffering heartache after a breakup.

Sorrow - an emotion of great sadness associated with loss or bereavement.

2. Grief, Sorrow : دکھ ہونا - افسوس ہونا : (Noun) Something that causes great unhappiness.

Her death was a great grief to John.

Campaign, Cause, Crusade, Drive, Effort, Movement - مقصد - a series of actions advancing a principle or tending toward a particular end; "he supported populist campaigns".

Death, Decease, Expiry - وفات - the event of dying or departure from life; "her death came as a terrible shock".

Especially, Particularly, Peculiarly, Specially - خاص طور پر - to a distinctly greater extent or degree than is common; "he was particularly fussy about spelling".

Great - بڑا - a person who has achieved distinction and honor in some field; "he is one of the greats of American music".

Acute, Intense - شدید - extremely sharp or intense; "acute pain".

Departure, Exit, Expiration, Going, Loss, Passing, Release - وصال - euphemistic expressions for death; "thousands mourned his passing".

Loved - محبوب - held dear; "his loved companion of many years".

One - ایک - a single person or thing; "Do I say one thing if you don`t mind ?".

Something - کچھ - An undetermined or unspecified thing; "Something went wrong with the car".

Grief, Sorrow - دکھ ہونا - something that causes great unhappiness; "her death was a great grief to John".

Sadness, Unhappiness - افسردگی - emotions experienced when not in a state of well-being.

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